Lipid sensing by gut CD1d calibrates peripheral serotonin release
نویسندگان
چکیده
Abstract The crosstalk between the immune and neuroendocrine system is critical for intestinal homeostasis gut-brain communications. However, it remains unclear how cells participate in gut sensation of hormones release response to environmental cues, such as self microbial lipids. We show here that lipid-mediated engagement invariant natural killer T (iNKT) with enterochromaffin (EC) cells, a subset epithelial promotes peripheral serotonin (5-HT) via CD1d-dependent manner, regulating motility hemostasis. CD1d ligation on EC transduces reverse signal restrains potassium conductance, leading calcium influx 5-HT secretion. Together, we by coupling iNKT chemosensory perceive lipid antigens calibrate release, modulating systemic physiology.
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.150.07